Necrotizing cellulitis with multiple abscesses on the leg caused by Serratia marcescens.
Identifieur interne : 000040 ( France/Analysis ); précédent : 000039; suivant : 000041Necrotizing cellulitis with multiple abscesses on the leg caused by Serratia marcescens.
Auteurs : Estelle Hau [France] ; Jean-David Bouaziz [France] ; Matthieu Lafaurie [France] ; Anne Saussine [France] ; Vincent Masson [France] ; Jonathan Rausky [France] ; Martine Bagot [France] ; Fabien Guibal [France]Source :
- Cutis [ 2326-6929 ] ; 2016.
Descripteurs français
- KwdFr :
- Abcès (anatomopathologie), Abcès (microbiologie), Antibactériens (usage thérapeutique), Cellulite sous-cutanée (anatomopathologie), Cellulite sous-cutanée (diagnostic), Cellulite sous-cutanée (microbiologie), Fasciite nécrosante (anatomopathologie), Fasciite nécrosante (diagnostic), Fasciite nécrosante (microbiologie), Femelle, Humains, Infections à Serratia (anatomopathologie), Infections à Serratia (diagnostic), Infections à Serratia (microbiologie), Jambe, Serratia marcescens (isolement et purification), Sujet âgé.
- MESH :
- anatomopathologie : Abcès, Cellulite sous-cutanée, Fasciite nécrosante, Infections à Serratia.
- diagnostic : Cellulite sous-cutanée, Fasciite nécrosante, Infections à Serratia.
- isolement et purification : Serratia marcescens.
- microbiologie : Abcès, Cellulite sous-cutanée, Fasciite nécrosante, Infections à Serratia.
- usage thérapeutique : Antibactériens.
- Femelle, Humains, Jambe, Sujet âgé.
English descriptors
- KwdEn :
- Abscess (microbiology), Abscess (pathology), Aged, Anti-Bacterial Agents (therapeutic use), Cellulitis (diagnosis), Cellulitis (microbiology), Cellulitis (pathology), Fasciitis, Necrotizing (diagnosis), Fasciitis, Necrotizing (microbiology), Fasciitis, Necrotizing (pathology), Female, Humans, Leg, Serratia Infections (diagnosis), Serratia Infections (microbiology), Serratia Infections (pathology), Serratia marcescens (isolation & purification).
- MESH :
- chemical , therapeutic use : Anti-Bacterial Agents.
- diagnosis : Cellulitis, Fasciitis, Necrotizing, Serratia Infections.
- isolation & purification : Serratia marcescens.
- microbiology : Abscess, Cellulitis, Fasciitis, Necrotizing, Serratia Infections.
- pathology : Abscess, Cellulitis, Fasciitis, Necrotizing, Serratia Infections.
- Aged, Female, Humans, Leg.
Abstract
Serratia marcescens is an unusual cause of severe skin infection initially described in immunocompromised patients. We report a case of necrotizing cellulitis of the leg caused by S marcescens in a 68-year-old woman with diabetes mellitus and a history of chronic lymphoedema of the leg. We reviewed the literature and found 49 cases of severe skin infections from S marcescens that included 20 cases of necrotizing fasciitis (NF) as well as 29 cases of severe skin infections without NF (non-NF cases). Patients were immunocompromised in 59% to 70% of cases. The mortality rate was high in NF cases (60%) versus non-NF cases (3%). Surgery was required in 95% of NF cases and in 24% of non-NF cases. The other clinical manifestations of S marcescens skin infection reported in the literature included disseminated papular eruptions in patients infected with human immunodeficiency virus with folliculitis on the trunk. Serratia marcescens is naturally resistant to amoxicillin alone and amoxicillin associated with clavulanic acid. Broad-spectrum antibiotics are indicated to treat S marcescens skin infections, and surgery should be promptly considered in cases of severe skin infections if appropriate antibiotic therapy does not lead to rapid improvement.
PubMed: 27023094
Affiliations:
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pubmed:27023094Le document en format XML
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AP-HP, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP</wicri:regionArea><wicri:noRegion>AP-HP</wicri:noRegion><wicri:noRegion>AP-HP</wicri:noRegion></affiliation></author><author><name sortKey="Guibal, Fabien" sort="Guibal, Fabien" uniqKey="Guibal F" first="Fabien" last="Guibal">Fabien Guibal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP</wicri:regionArea><wicri:noRegion>AP-HP</wicri:noRegion><wicri:noRegion>AP-HP</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cutis</title><idno type="eISSN">2326-6929</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abscess (microbiology)</term><term>Abscess (pathology)</term><term>Aged</term><term>Anti-Bacterial Agents (therapeutic use)</term><term>Cellulitis (diagnosis)</term><term>Cellulitis (microbiology)</term><term>Cellulitis (pathology)</term><term>Fasciitis, Necrotizing (diagnosis)</term><term>Fasciitis, Necrotizing (microbiology)</term><term>Fasciitis, Necrotizing (pathology)</term><term>Female</term><term>Humans</term><term>Leg</term><term>Serratia Infections (diagnosis)</term><term>Serratia Infections (microbiology)</term><term>Serratia Infections (pathology)</term><term>Serratia marcescens (isolation & purification)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Abcès (anatomopathologie)</term><term>Abcès (microbiologie)</term><term>Antibactériens (usage thérapeutique)</term><term>Cellulite sous-cutanée (anatomopathologie)</term><term>Cellulite sous-cutanée (diagnostic)</term><term>Cellulite sous-cutanée (microbiologie)</term><term>Fasciite nécrosante (anatomopathologie)</term><term>Fasciite nécrosante (diagnostic)</term><term>Fasciite nécrosante (microbiologie)</term><term>Femelle</term><term>Humains</term><term>Infections à Serratia (anatomopathologie)</term><term>Infections à Serratia (diagnostic)</term><term>Infections à Serratia (microbiologie)</term><term>Jambe</term><term>Serratia marcescens (isolement et purification)</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Bacterial Agents</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Abcès</term><term>Cellulite sous-cutanée</term><term>Fasciite nécrosante</term><term>Infections à Serratia</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cellulitis</term><term>Fasciitis, Necrotizing</term><term>Serratia Infections</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Cellulite sous-cutanée</term><term>Fasciite nécrosante</term><term>Infections à Serratia</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Serratia marcescens</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Serratia marcescens</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Abcès</term><term>Cellulite sous-cutanée</term><term>Fasciite nécrosante</term><term>Infections à Serratia</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Abscess</term><term>Cellulitis</term><term>Fasciitis, Necrotizing</term><term>Serratia Infections</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Abscess</term><term>Cellulitis</term><term>Fasciitis, Necrotizing</term><term>Serratia Infections</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antibactériens</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Leg</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Jambe</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Serratia marcescens is an unusual cause of severe skin infection initially described in immunocompromised patients. We report a case of necrotizing cellulitis of the leg caused by S marcescens in a 68-year-old woman with diabetes mellitus and a history of chronic lymphoedema of the leg. We reviewed the literature and found 49 cases of severe skin infections from S marcescens that included 20 cases of necrotizing fasciitis (NF) as well as 29 cases of severe skin infections without NF (non-NF cases). Patients were immunocompromised in 59% to 70% of cases. The mortality rate was high in NF cases (60%) versus non-NF cases (3%). Surgery was required in 95% of NF cases and in 24% of non-NF cases. The other clinical manifestations of S marcescens skin infection reported in the literature included disseminated papular eruptions in patients infected with human immunodeficiency virus with folliculitis on the trunk. Serratia marcescens is naturally resistant to amoxicillin alone and amoxicillin associated with clavulanic acid. Broad-spectrum antibiotics are indicated to treat S marcescens skin infections, and surgery should be promptly considered in cases of severe skin infections if appropriate antibiotic therapy does not lead to rapid improvement.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Hau, Estelle" sort="Hau, Estelle" uniqKey="Hau E" first="Estelle" last="Hau">Estelle Hau</name></noRegion><name sortKey="Bagot, Martine" sort="Bagot, Martine" uniqKey="Bagot M" first="Martine" last="Bagot">Martine Bagot</name><name sortKey="Bouaziz, Jean David" sort="Bouaziz, Jean David" uniqKey="Bouaziz J" first="Jean-David" last="Bouaziz">Jean-David Bouaziz</name><name sortKey="Guibal, Fabien" sort="Guibal, Fabien" uniqKey="Guibal F" first="Fabien" last="Guibal">Fabien Guibal</name><name sortKey="Lafaurie, Matthieu" sort="Lafaurie, Matthieu" uniqKey="Lafaurie M" first="Matthieu" last="Lafaurie">Matthieu Lafaurie</name><name sortKey="Masson, Vincent" sort="Masson, Vincent" uniqKey="Masson V" first="Vincent" last="Masson">Vincent Masson</name><name sortKey="Rausky, Jonathan" sort="Rausky, Jonathan" uniqKey="Rausky J" first="Jonathan" last="Rausky">Jonathan Rausky</name><name sortKey="Saussine, Anne" sort="Saussine, Anne" uniqKey="Saussine A" first="Anne" last="Saussine">Anne Saussine</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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